Doi, Toshihiko http://orcid.org/0000-0003-2042-6829
Fujiwara, Yutaka
Matsubara, Nobuaki
Tomomatsu, Junichi http://orcid.org/0000-0002-2130-5183
Iwasa, Satoru
Tanaka, Akari http://orcid.org/0000-0003-4674-6636
Endo-Tsukude, Chihiro http://orcid.org/0000-0002-1735-1056
Nakagawa, Shintaro
Takahashi, Shunji http://orcid.org/0000-0002-5031-1953
Funding for this research was provided by:
Chugai Pharmaceutical
Article History
Received: 14 January 2019
Accepted: 31 May 2019
First Online: 21 June 2019
Compliance with ethical standards
:
: TD has received research grant from Taiho, Novartis, Merck Serono, Astellas, MSD, Janssen, Boehringer Ingelheim, Takeda, Pfizer, Eli Lilly, Sumitomo Dainippon, Chugai, Kyowa Hakko Kirin, Daiichi Sankyo, Celegene, BMS, Abbvie, and Quintiles, and consultant fee from Eli Lilly, Chugai, Kyowa Hakko Kirin, MSD, Daiichi Sankyo, Amgen, Sumitomo Dainippon, and Taiho. YF has received research funding from Chugai for the current study, as well as research funding grants from AbbVie, AstraZeneca, BMS, Daiichi Sankyo, Eisai, Eli Lilly, Incyte, Merck Serono, MSD, and Novartis for other research. YF has also received fees from AstraZeneca, BMS, Novartis, and ONO for participating in advisory boards, and from BMS, ONO, and Taiho as a member of their speakers’ bureau, outside of the submitted work. NM has received research grant from Bayer, AstraZeneca, Taiho, MSD, Janssen, Chugai, Eli Lilly, Sanofi, Astellas, Eisai, and Shionogi, and lecture fees from MSD, AstraZeneca, Eisai, Ono, Kissei, Sanofi, Takeda, Chugai, BMS, Novartis, Bayer, Janssen, and Pfizer. JT has received fee from Eisai as an employment medical advisor. SI has received research grant from BMS, Eli Lilly, Eisai, Chugai, Daiichi Sankyo, Novartis, Merck Serono, Bayer, and Otsuka, and lecture fees from Eli Lilly, Chugai, and Taiho. AT, CE, and SN are employees of Chugai Pharmaceutical Co., Ltd. ST has received research funding from Chugai for the current study, fees from Novartis, MSD, Eisai, Taiho, Chugai, Daiichi Sankyo, Bayer, and AstraZeneca for advisory work, and research grants from MSD, Eisai, Taiho, Chugai, Daiichi Sankyo, Bayer, AstraZeneca, and Quintiles, outside of the submitted work.
: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
: Informed consent was obtained from all individual participants included in the study.