Roth, Melanie http://orcid.org/0000-0002-8409-4512
Emmanuel, Katja
Wirth, Wolfgang
Kwoh, C. Kent
Hunter, David J.
Eckstein, Felix
Funding for this research was provided by:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (N01-AR-2-2260-13-0-1, HHSN268201000021C)
Article History
Received: 16 July 2017
Accepted: 17 October 2017
First Online: 24 November 2017
Compliance with ethical standards
:
: The scientific guarantor of this publication is Felix Eckstein.
: The authors of this manuscript declare relationships with the following companies: Wolfgang Wirth has a part time employment with Chondrometrics GmbH and is a co-owner of Chondrometrics GmbH, a company providing MR image analysis services to academic researchers and to industry. C. Kent Kwoh has received research support from Merck Serono and Abbvie. David J. Hunter is supported by an NHMRC practitioner Fellowship and consults for Flexion, Merck Serono and TissueGene. Felix Eckstein is CEO and CMO of Chondrometrics GmbH; he has provided consulting services to Merck Serono, Bioclinica/Synarc, Samumed and Abbvie, has prepared educational sessions for Medtronic, and has received research support from Pfizer, Eli Lilly, Merck Serono, Novartis, Stryker, Abbvie, Kolon/Tissue Gene, Synarc, Ampio, BICL and Orthotrophix. Katja Emmanuel and Melanie Roth declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
: No complex statistical methods were necessary for this paper.
: The OAI was approved by the institutional review board for the University of California, San Francisco and its affiliates (approval no. H5254-20499-09)
: All patients provided written informed consent.
: Some study subjects or cohorts have been previously reported in Osteoarthritis and Cartilage (2014) <i>“Trajectory of cartilage loss within 4 years of knee replacement – a nested case-control study form the Osteoarthritis Initiative”</i> by Eckstein et al., in Annals of the Rheumatic Diseases (2013) <i>“Quantitative magnetic resonance imaging measures of cartilage predict knee replacement - a case-control study from the Osteoarthritis Initiative”</i> by Eckstein et al. and in European Radiology (2016) <i>“Comparison of radiographic joint space width and magnetic resonance imaging for prediction of knee replacement: A longitudinal case-control study from the Osteoarthritis Initiative”</i> by Eckstein et al. The previous work focussed on cartilage thickness and joint space width but did not assess or evaluate 3D meniscal measures.
: • retrospective• observational• multicentre