Li, Chao http://orcid.org/0000-0002-0734-0011
Wang, Shuo
Serra, Angela
Torheim, Turid
Yan, Jiun-Lin
Boonzaier, Natalie R.
Huang, Yuan
Matys, Tomasz
McLean, Mary A.
Markowetz, Florian
Price, Stephen J.
Funding for this research was provided by:
National Institute for Health Research (NIHR/CS/009/011))
Cancer Research UK (C14303/A17197 and A19274)
Cambridge Commonwealth, European and International Trust
China Scholarship Council
Chang Gung Medical Foundation
Engineering and Physical Sciences Research Council
Article History
Received: 2 November 2018
Accepted: 18 December 2018
First Online: 1 February 2019
Compliance with ethical standards
:
: The scientific guarantor of this publication is Dr. Stephen Price.
: The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
: One of the authors (Dr. Angela Serra) has significant statistical expertise. Dr. Jingjing Zou (Statistical laboratory, Centre for Mathematical Sciences, University of Cambridge, United Kingdom) provided statistical advice.
: Written informed consent was obtained from all subjects (patients) in this study.
: Institutional Review Board approval was obtained.Ethical committee: Cambridgeshire 2 LREC.Ethics Reference No.: 10/H0308/23.
: Some study subjects reported in this study were reported in a previous study [CitationRef removed], in which DTI decomposition was used to reflect the intra-tumoral heterogeneity of tumor infiltration. This current study aims to integrate diffusion and perfusion imaging to investigate the inter-tumoral heterogeneity.
: • retrospective• diagnostic or prognostic study• performed at one institution