Nagel, Sebastian N. http://orcid.org/0000-0002-9489-2913
Steffen, Ingo G.
Schwartz, Stefan
Hamm, Bernd
Elgeti, Thomas
Article History
Received: 9 November 2018
Revised: 14 December 2018
Accepted: 24 January 2019
First Online: 19 February 2019
Compliance with ethical standards
:
: The scientific guarantor of this publication is Sebastian Nagel.
: The authors of this manuscript declare relationships with the following companies:Bernd Hamm is Grant Recipient for the Department of Radiology, Charité, and has further received funding from Abbott, AbbVie, Ablative Solutions, Accovion, Achaogen Inc., Actelion Pharmaceuticals, ADIR, Aesculap, AGO, AIF Arbeitsgemeinschaft industrieller Forschungsvereinigungen, AIO Arbeitsgemeinschaft lnternistische Onkologie, Alexion Pharmaceuticals, Amgen, AO Foundation, Arena Pharmaceuticals, art photonics GmbH Berlin, ASR Advanced sleep research, Astellas, AstraZeneca, BARD, Bayer Healthcare, Bayer Schering Pharma, Bayer Vital, BBraun, Berlin-Brandenburger Centrum für Regenerative Therapien (BCRT), Berliner Krebsgesellschaft, Biotronik, Bioven, BMBF Bundesministerium für Bildung und Forschung, Boehring Ingelheimer, Boston Biomedical Inc., BRACCO Group, Brainsgate, Bristol-Myers Squibb, Cascadian Therapeutics, Inc., Celgene, CELLACT Pharma, Celldex Therapeutics, CeIoNova BioSciences, Charité research organisation GmbH, Chiltern, CCovance, CUBIST, Curis, Daiichi, DC Devices, Inc. USA, Delcath Systems, Dermira Inc., Deutsche Krebshilfe, Deutsche Rheuma Liga, DFG, DSM Nutritional Products AG, Dt. Stiftung für Herzforschung, Dynavax, Eisai Ltd.‚ European Knowledge Centre, Mosquito Way, Hatfield, Eli Lilly and Company Ltd., EORTC, Epizyme, Inc., Essex Pharma, EU Programmes, Euroscreen S.A., Fibrex Medical Inc., Focused Ultrasound Surgery Foundation, Fraunhofer Gesellschaft, Galena Biopharma, Galmed Research and Development Ltd., Ganymed, GE, Genentech. Inc., GETNE (Grupo Español de Tumores Neuroendocrinos), Gilead Sciences, Inc., Glaxo Smith Kline, Glycotope GmbH, Berlin, Goethe Uni Frankfurt, Guerbet, Guidant Europe NV, Halozyme, Holaira Inc., ICON (CRO), Immunomedics Inc., Immunocore, Incyte, INC Research, Innate Pharma, InSightec Ltd., Inspiremd, inVentiv Health Clinical UK Ltd, Inventivhealth, IOMEDICO, IONIS, IPSEN Pharma, ISA Therapeutics, lsis Pharmaceuticals Inc., ITM Solution GmbH, Jansen, Kantar Health GmbH (CRO), Karyopharm Therapeutics, Inc., Kendle/MorphoSys AG, Kite Pharma, La Roche, Land Berlin, Lilly GmbH, Lion Biotechnology, Lombard Medical, Loxo Oncology, Inc, LSK BioPartners, USA; Lundbeck GmbH, LUX Biosciences, LYSARC, MacroGenics, MagForce, Medlmmune Inc., Medlmmune Limited, Medpace, Medpace Germany GmbH (CRO), MedPass (CRO), Medronic, Merck, Merrimack Pharmaceuticals Inc, MeVis Medical Solutions AG, Millennium Pharmaceuticals Inc., Mologen, MSD Sharp, NeoVacs SA, Nexus Oncology, Novartis, novocure, Nuvisan, Ockham oncology, Orion Corporation Orion Pharma, Parexel CRO Service, Perceptive, Pfizer GmbH, Pharma Mar, Pharmaceutical Research Associates GmbH (PRA), Pharmacyclics Inc., Philipps, PIQUR Therapeutics Ltd., Pluristem, Portola Pharmaceuticals, PPD (CRO), PRAint, Premier-research, Provectus Biopharmaceuticals, Inc., psi-cro, Pulmonx International Sàrl, Quintiles Gmbh, Respicardia, Roche, Samsung, Sanofi, sanofis-aventis S.A, Schumacher GmbH, Seattle Genetics, Servier (CRO), SGS Life Science Services (CRO), Siemens, Silena Therapeutics, Spectranetics GmbH, Spectrum Pharmaceuticals, St. Jude Medical, Stiftung Wolfgang Schulze, Symphogen, Taiho Pharmaceutical Co., Taqu Therapeutics Ltd., Terumo Medical Corporation, Tesaro, TETEC AG, TEVA, Theorem, Theradex, Threshold Pharmaceuticals Inc., TNS Healthcare GmbH, Toshiba, UCB Pharma, Uni München, VDI/VDE, Winicker Norimed, Wyeth Pharma, Xcovery Holding Company, Zukunftsfond Berlin (TSB).Stefan Schwartz is receiving grants from Pfizer and Enzon.
: One of the authors (Ingo Steffen) has significant statistical expertise.
: Written informed consent was waived by the Institutional Review Board.
: Institutional Review Board approval was obtained.
: • This study is a retrospective study performed at one institution on the diagnostic performance of clinical decision rules and D-dimer measurements in patients who had undergone computed tomography angiography in the diagnostic workup of suspected pulmonary embolism.