Funding for this research was provided by:
Bayer (not applicable)
Text and Data Mining valid from 2019-04-23
Received: 28 November 2018
Revised: 27 February 2019
Accepted: 22 March 2019
First Online: 23 April 2019
Compliance with ethical standards
: The scientific guarantor of this publication is Koen Nieman.
: Koen Nieman declared institutional research support from Siemens Healthineers, GE Healthcare, Bayer Healthcare, and Heartflow Inc.Joachim E. Wildberger declared institutional research grants from AGFA Healthcare, Bayer Healthcare, GE Healthcare, Philips Healthcare, Siemens Healthcare, and Optimed as well as personal disclosures (Speaker’s bureau) from Bayer and Siemens.Marco Das declared institutional research grants at the time of the study from Bayer Healthcare, Philips Healthcare, and Siemens Healthcare as well as personal disclosures (Speaker’s bureau) from Bayer and Siemens and Cook Medical.Andrea Laghi declared personal disclosure (Speaker’s bureau) from Bayer, Bracco, GE Healthcare, Merck, and Bristol-Myers Squibb.The other authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
: One of the authors has significant statistical expertise.
: Written informed consent was obtained from all subjects (patients) in this study.
: Institutional Review Board approval was obtained.
: • prospective.• randomized controlled trial.• multicenter study.