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Article History

Received: 23 May 2019

Revised: 8 August 2019

Accepted: 12 September 2019

First Online: 17 January 2020

Compliance with ethical standards

:

: The scientific guarantor of this publication is Kartik Jhaveri.

: The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

: One of the authors has significant statistical expertise.

: Written informed consent was obtained from all subjects (patients) in this study.

: Institutional Review Board approval was obtained.

: All MRI data used in this manuscript were acquired as part of a previous study (Jhaveri et al, JMRI 2018, pp. 1467–1474). The purpose of this previous study was twofold: first, to define a calibration curve that related R2*-derived liver iron concentration (LIC) values to FerriScan-derived LIC values; second, to characterize the nature of the uncertainty in the relationship between those two quantities. In the present manuscript, (simulated) clinical decisions were made using the R2*- and FerriScan-derived LIC values respectively. An analysis was performed to determine the agreement in clinical decision-making between these two approaches. Although the same data is used for both studies, there is no overlap in the nature or scope of the work.

: • diagnostic or prognostic study• performed at one institution