Received: 23 May 2019
Revised: 8 August 2019
Accepted: 12 September 2019
First Online: 17 January 2020
Compliance with ethical standards
: The scientific guarantor of this publication is Kartik Jhaveri.
: The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
: One of the authors has significant statistical expertise.
: Written informed consent was obtained from all subjects (patients) in this study.
: Institutional Review Board approval was obtained.
: All MRI data used in this manuscript were acquired as part of a previous study (Jhaveri et al, JMRI 2018, pp. 1467–1474). The purpose of this previous study was twofold: first, to define a calibration curve that related R2*-derived liver iron concentration (LIC) values to FerriScan-derived LIC values; second, to characterize the nature of the uncertainty in the relationship between those two quantities. In the present manuscript, (simulated) clinical decisions were made using the R2*- and FerriScan-derived LIC values respectively. An analysis was performed to determine the agreement in clinical decision-making between these two approaches. Although the same data is used for both studies, there is no overlap in the nature or scope of the work.
: • diagnostic or prognostic study• performed at one institution