Kuo, Wieying
,
Perez-Rovira, Adria
Tiddens, Harm
de Bruijne, Marleen http://orcid.org/0000-0002-6328-902X
Funding for this research was provided by:
Nederlandse cystic fibrosis stichting (-)
Steun door Zeevaart (679)
Netherlands Organisation for Scientific Research (639.022.010)
Danish Council for Independent Research (4093-00313B)
Article History
Received: 8 May 2019
Revised: 13 November 2019
Accepted: 3 December 2019
First Online: 5 February 2020
Compliance with ethical standards
:
: The scientific guarantor of this publication is Marleen de Bruijne.
: The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.
: No complex statistical methods were necessary for this paper.
: Written informed consent was waived by the Institutional Review Board.
: Institutional Review Board approval was obtained.
: Some study subjects or cohorts have been previously reported in <i>European Radiology</i>, <i>Journal of Cystic Fibrosis</i>, <i>American Journal of Roentgenology</i> and <i>Medical Physics</i>. From the 180 subjects analysed in our manuscript, 24 have been previously reported (1–3). These previous publications reported airway–artery ratios that were measured manually (1) or automatically (2), and compared with visual scores (CFCT and PRAGMA) (3). Additionally, 156 control CTs were part of the Normal Chest CT study group. This collaboration was established in order to establish normative data of the airways on chest CT in a paediatric population. Previous work included normative data of the central airway dimensions (4). Copies of all published manuscripts added with submission. The difference with this current manuscript is that this study describes the automatically acquired airway dimensions and most importantly focuses on tapering values, which has not been described in such a population before. It estimates the tapering value in a control paediatric population and compares tapering values between patients with known bronchiectasis and control subjects1. Kuo W, De Bruijne M, Petersen J, Nasserinejad K, Ozturk H, Chen Y, et al. Diagnosis of bronchiectasis and airway wall thickening in children with cystic fibrosis: Objective airway-artery quantification. Eur Radiol. European Radiology; 2017;27:4680–9.2. Perez-Rovira A, Kuo W, Petersen J, Tiddens HA, de Bruijne M. Automatic airway–artery analysis on lung CT to quantify airway wall thickening and bronchiectasis. Med Phys. 2016;43(10):5736–44.3. Kuo W, Andrinopoulou E-R, Perez-Rovira A, Ozturk H, de Bruijne M, Tiddens HAWM. Objective airway artery dimensions compared to CT scoring methods assessing structural cystic fibrosis lung disease. J Cyst Fibros. European Cystic Fibrosis Society.; 2017;16(1):116–23.4. Kuo W, Ciet P, Andrinopoulou E-R et al. Reference Values for Central Airway Dimensions on CT Images of Children and Adolescents. AJR Am J Roentgenol. American Roentgen Ray Society; 2018 Feb 20;210(2):423–30.
: • Retrospective• Diagnostic or prognostic study• Multicentre study