Cannella, Roberto
Vernuccio, Federica
Sagreiya, Hersh
Choudhury, Kingshuk Roy
Iranpour, Negaur
Marin, Daniele
Furlan, Alessandro
Article History
Received: 2 September 2019
Revised: 8 November 2019
Accepted: 31 January 2020
First Online: 27 February 2020
Compliance with ethical standards
:
: The scientific guarantor of this publication is Alessandro Furlan.
: The authors of this manuscript declare relationships with the following companies: Daniele Marin: research support from Siemens Healthineers; and Alessandro Furlan: royalties from Elsevier/Amirsys and consultant for Bracco.
: Two of the authors (Hersh Sagreiya and Kingshuk Roy Choudhury) have significant statistical expertise.
: Written informed consent was waived by the Institutional Review Board.
: Institutional Review Board approval was obtained.
: We would like to specify that 104/155 patients were included in a previous study (title: LI-RADS: diagnostic performance of hepatobiliary phase hypointensity and major imaging features of LR-3 and LR-4 lesions measuring 10–19 mm with arterial phase hyperenhancement) where we reported the diagnostic performance of the HBP hypointensity and major features in LR-3 and LR-4 observations with APHE measuring 10–19 mm and classified according to LI-RADS v2017. Conversely, in this study, we aim at investigating the diagnostic performance of all AFs favoring malignancy, not only HBP hypointensity, for the diagnosis of HCC using the LI-RADS v2018.
: • Retrospective• Diagnostic or prognostic study• Multicenter study