Nous, Fay M. A.
Budde, Ricardo P. J.
Lubbers, Marisa M.
Yamasaki, Yuzo
Kardys, Isabella
Bruning, Tobias A.
Akkerhuis, Jurgen M.
Kofflard, Marcel J. M.
Kietselaer, Bas
Galema, Tjebbe W.
Nieman, Koen
Funding for this research was provided by:
Hartstichting (NHS 2014T061, NHS 2013T071)
Article History
Received: 6 December 2019
Revised: 12 February 2020
Accepted: 25 February 2020
First Online: 12 March 2020
Compliance with ethical standards
:
: The scientific guarantor of this publication is Koen Nieman.
: The authors of this manuscript declare relationships with the following companies: Siemens Healthineers, HeartFlow, GE Healthcare, Bayer Healthcare.
: Isabella Kardys kindly provided statistical advice for this manuscript.
: Written informed consent was obtained from all subjects (patients) in this study.
: Institutional Review Board approval was obtained.
: All subjects have been previously reported in the CRESCENT I and CRESCENT II trials. The prior studies evaluated the clinical effectiveness of a tiered cardiac CT approach against standard functional testing. The current study expands on these studies by combing the subjects of the CT arm of both studies and implement CT-FFR analyses into the protocol. The previous studies were published in European Heart Journal (CRESCENT I trial) and JACC Cardiovascular Imaging (CRESCENT II trial).
: • Retrospective• Observational• Multicenter study