Received: 26 March 2020
Revised: 5 May 2020
Accepted: 29 May 2020
First Online: 13 June 2020
Compliance with ethical standards
: The scientific guarantor of this publication is Dr. Àlex Rovira (Neuroradiology Section, Department of Radiology (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Pg. Vall d’Hebron 119-129, 08035 Barcelona, Spain).
: The authors of this manuscript declare relationships with the following companies:Dr. Àlex Rovira serves on scientific advisory boards for Novartis, Sanofi-Genzyme, SyntheticMR, Bayer, Roche, Biogen, Neurodiem and OLEA Medical, and has received speaker honoraria from Bayer, Sanofi-Genzyme, Bracco, Merck-Serono, Teva Pharmaceutical Industries Ltd, Novartis, Roche, and Biogen.The remaining authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.
: Two of the authors (Dr. Giovanni Caruana and Dr. Roberto Cannella) have significant statistical expertise.
: Written informed consent was obtained from all subjects (patients) in this study.
: Institutional Review Board approval was not required because this was a retrospective study and all the patients who underwent MRI provided written informed consent for the use of their anonymized MR studies for research purposes.
: • retrospective• diagnostic study• performed at one institution