Ahmed, Firas S. http://orcid.org/0000-0001-9616-9297
Dercle, Laurent
Goldmacher, Gregory V.
Yang, Hao
Connors, Dana
Tang, Ying
Karovic, Sanja
Zhao, Binsheng
Carvajal, Richard D.
Robert, Caroline
Maitland, Michael L.
Oxnard, Geoffrey R.
Schwartz, Lawrence H.
Funding for this research was provided by:
Foundation for the National Institutes of Health
Article History
Received: 24 April 2020
Revised: 17 July 2020
Accepted: 31 August 2020
First Online: 30 September 2020
Compliance with ethical standards
:
: The scientific guarantor of this publication:Lawrence H. Schwartz, MD
: The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.
: One of the authors, Laurent Dercle, MD, PhD, has significant statistical expertise.No complex statistical methods were necessary for this paper.
: Written informed consent was not required for this study because the study is a retrospective analysis of imaging that had already been collected during KEYNOTE-002 clinical trial.
: Institutional Review Board approval was obtained for the KEYNOTE-002 clinical trial.Institutional Review Board approval was not required for this retrospective study of the de-identified imaging data which was collected during KEYNOTE-002 clinical trial.
: Some study subjects or cohorts have been previously reported in the original publication of KEYNOTE-002 clinical trial manuscript in Lancet Oncology: ExternalRef removed
: • Retrospective• Randomized controlled trial (only the immunotherapy arm)• Multicenter study