Kristoffersen, Per Martin http://orcid.org/0000-0001-6471-8861
Bråten, Lars C. H.
Vetti, Nils
Grøvle, Lars
Hellum, Christian
Storheim, Kjersti
Zwart, John-Anker
Assmus, Jörg
Espeland, Ansgar
Funding for this research was provided by:
Helse Sør-Øst RHF (2015-090)
Helse Vest (HV 911891, HV 911938)
Article History
Received: 7 July 2020
Revised: 23 October 2020
Accepted: 18 November 2020
First Online: 27 November 2020
Compliance with ethical standards
:
: The scientific guarantor of this publication is Per Martin Kristoffersen.
: The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
: One of the authors has significant statistical expertise.
: Written informed consent was obtained from all patients in this study.
: Institutional Review Board approval was obtained from the Regional Committee for Medical Research Ethics – South East Norway (reference no. 2014/158).
: Some study subjects or cohorts have been previously reported in (a) Braten LCH et al Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre trial. BMJ 2019;367:l5654, (b) Kristoffersen PM et al Short tau inversion recovery MRI of Modic changes: a reliability study. Acta Radiol Open 2020;9(1):2058460120902402, (c) Braten LCH et al Association of Modic change types and their short tau inversion recovery signals with clinical characteristics- a cross sectional study of chronic low back pain patients in the AIM study. BMC Musculoskelet Disord 2020;21(1):368, (d) Grotle M et al Cost-utility analysis of antibiotic treatment in patients with chronic low back pain and Modic changes: results from a randomised, placebo-controlled trial in Norway (the AIM study). BMJ Open 2020;10(6):e035461, and (e) Braten LCH et al Clinical effect modifiers of antibiotic treatment in patients with chronic low back pain and Modic changes - Secondary analyses of a randomised, placebo-controlled trial (the AIM study) (<i>accepted</i>, BMC Musculoskelet Disord).
: • prospective• randomised controlled trial (subgroup analysis)• multicentre study