MacKay, James W. http://orcid.org/0000-0001-7558-3800
Nezhad, Faezeh Sanaei
Rifai, Tamam
Kaggie, Joshua D.
Naish, Josephine H.
Roberts, Caleb
Graves, Martin J.
Waterton, John C.
Janiczek, Robert L.
Roberts, Alexandra R.
McCaskie, Andrew
Gilbert, Fiona J.
Parker, Geoff J. M.
Funding for this research was provided by:
Experimental Medicine Initiative, University of Cambridge (RG81329)
GlaxoSmithKline (RG87552)
Article History
Received: 30 July 2020
Revised: 7 November 2020
Accepted: 19 January 2021
First Online: 16 February 2021
Declarations
:
: The scientific guarantor of this publication is Dr James MacKay.
: The authors of this manuscript declare relationships with the following companies:Dr Faezeh Sanaei Nezhad, Dr Josephine Naish, Dr Caleb Roberts, Dr Alex Roberts, Prof John Waterton and Prof Geoff Parker are current or former employees or affiliates of BiOxyDyn, a for-profit company engaged in the discovery, development, and marketing of imaging biomarkers.The other authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.
: One of the authors has significant statistical expertise.
: Written informed consent was obtained from all subjects (patients) in this study.
: Local Research Ethics Committee approval was obtained (Cambridge Central Local Research Ethics Committee (Ref CitationRef removed/EE/0402))
: Some study subjects or cohorts have been previously reported in MacKay JW, Kaggie JD, Treece GM, et al Three-dimensional surface-based analysis of cartilage MRI data in knee osteoarthritis: validation and initial clinical application. <i>Journal of Magnetic Resonance Imaging</i>: ExternalRef removed. This manuscript reports on the same study cohort but focusses on analysis of articular cartilage in contrast to the current manuscript which describes a completely separate set of analyses of synovitis.
: • prospective• experimental• performed at one institution