Wang, Yifei http://orcid.org/0000-0002-1632-2050
Chu, Philip
Szczykutowicz, Timothy P.
Stewart, Carly
Smith-Bindman, Rebecca
Funding for this research was provided by:
United States National Institute of Health (R01- CA181191)
Patient-Centered Outcomes Research Institute (DI-2018C1-11375)
Article History
Received: 8 August 2022
Revised: 20 July 2023
Accepted: 3 August 2023
First Online: 30 August 2023
Declarations
:
: The scientific guarantor of this publication is Yifei Wang.
: Timothy P. Szczykutowicz receives research support from GE Healthcare and Canon Medical USA. He is a consultant to Imalogix, AstoCT/LeoCancer Care, AiDoc, FlowHow.ai, and ALARA Imaging. IP Royalties from FlowHow.ai, Qaelum.Rebecca Smith-Bindman is a founder of Alara Imaging, Inc., a company focused on collecting and reporting radiation dose information associated with CT.
: Yifei Wang kindly provided statistical advice for this manuscript.
: Written informed consent was waived by the Institutional Review Board.
: Institutional Review Board approval was obtained.
: This study was completed using data assembled in the University of California, San Francisco International CT Dose Registry, previously described in several papers, including:Smith-Bindman R, Wang Y, Chu P, Chung R, Einstein AJ, Balcombe J, Cocker M, Das M, Delman BN, Flynn M, Gould R, Lee RK, Yellen-Nelson T, Schindera S, Seibert A, Starkey J, Suntharalingam S, Wetter A, Wildberger JE, Miglioretti DL. International variation in radiation dose for computed tomography examinations: prospective cohort study. <i>BMJ</i> (Clinical research ed) 2019;364:k4931. ExternalRef removedSmith-Bindman R, Chu P, Wang Y, Chung R, Lopez-Solano N, Einstein AJ, Solberg L, Cervantes LF, Yellen-Nelson T, Boswell W, Delman BN, Duong PA, Goode AR, Kasraie N, Lee RK, Neill R, Pahwa A, Pike P, Roehm J, Schindera S, Starkey J, Suntharalingam S, Jeukens C, Miglioretti DL. Comparison of the Effectiveness of Single-Component and Multicomponent Interventions for Reducing Radiation Doses in Patients Undergoing Computed Tomography: A Randomized Clinical Trial. JAMA internal medicine 2020; <i>JAMA Intern Med</i>. 2020;180(5):666–675. ExternalRef removedChu PW, Yu S, Wang Y, Seibert JA, Cervantes LF, Kasraie N, Chu CA, Smith-Bindman R. Reference phantom selection in pediatric computed tomography using data from a large, multicenter registry. <i>Pediatric Radiology</i> 2022;52(3):445–452. ExternalRef removedBos D, Yu S, Luong J, Chu P, Wang Y, Einstein AJ, Starkey J, Delman BN, Duong PT, Das M, Schindera S, Goode AR, MacLeod F, Wetter A, Neill R, Lee RK, Roehm J, Seibert JA, Cervantes LF, Kasraie N, Pike P, Pahwa A, Jeukens CRLPN, Smith-Bindman R. Diagnostic reference levels and median doses for common clinical indications of CT: findings from an international registry. <i>Eur Radiol</i>. 2021 Oct 13. ExternalRef removed. Epub ahead of print. PMID: 34642811.These previously published studies featured most or all patients featured in our study. Subject matter of these previously published studies, however, are unrelated to the manipulation of CT acquisition parameters and their impact on observed radiation dose distributions, which is the subject of our study.
: • prospective• observational• multicenter study