Szabo, Liliana http://orcid.org/0000-0002-4699-3648
Salih, Ahmed
Pujadas, Esmeralda Ruiz
Bard, Andrew
McCracken, Celeste
Ardissino, Maddalena
Antoniades, Charalambos
Vago, Hajnalka
Maurovich-Horvat, Pal
Merkely, Bela
Neubauer, Stefan
Lekadir, Karim
Petersen, Steffen E.
Raisi-Estabragh, Zahra
Article History
Received: 6 February 2023
Revised: 17 August 2023
Accepted: 7 September 2023
First Online: 21 November 2023
Declarations
:
: The scientific guarantor of this publication is Prof. Steffen Petersen.
: SEP provides consultancy to Circle Cardiovascular Imaging Inc, Calgary, Alberta, Canada. CA and SN are Founders, Shareholders, and Directors of Caristo Diagnostics, a CT Image analysis spinout company from the University of Oxford. CA is also the inventor of relevant patents US10,695,023B2, PCT/GB2017/053262, GB2018/1818049.7, GR20180100490, and GR20180100510, licensed through exclusive license to Caristo Diagnostics. The remaining authors have no disclosures.
: AS and CM have significant statistical expertise and extensive experience working with UK Biobank data. AS led analysis and model development steps. CM led the creation of diagnostic labels, and performed dataset creation for all non-radiomic features.
: Written informed consent was obtained from all subjects (patients) in this study.
: This study complies with the Declaration of Helsinki; the work was covered by the ethical approval for UK Biobank studies from the National Health Service (NHS) National Research Ethics Service on 17 June 2011 (Ref 11/NW/0382) and extended on 18 June 2021 (Ref 21/NW/0157) with written informed consent obtained from all participants.
: This research was conducted using the UK Biobank resource under access application 2964. UK Biobank will make the data available to all bona fide researchers for all types of health-related research that is in the public interest, without preferential or exclusive access for any persons. All researchers will be subject to the same application process and approval criteria as specified by UK Biobank. For more details on the access procedure, see the UK Biobank website: ExternalRef removed. Automated, quality-controlled pericardial adipose tissue segmentation was conducted in a previous publication by our research group (Bard et al, ExternalRef removed). This article is referenced in the manuscript. Of note, the current study is not an extension but rather a completely new layer of the research conducted using pericardial adipose tissue analysis. The analysis and model development of this study were conducted independently.
: •observational•multicentre study