van der Kamp, Laura T. http://orcid.org/0000-0002-0702-7199
Edjlali, Myriam
Naggara, Olivier
Matsushige, Toshinori
Bulters, Diederik O.
Digpal, Ronneil
Zhu, Chengcheng
Saloner, David
Hu, Peng
Zhai, Xiaodong
Mossa-Basha, Mahmud
Tian, Bing
Sakamoto, Shigeyuki
Fu, Qichang
Ruigrok, Ynte M.
Zhao, Huilin
Chen, Huijun
Rinkel, Gabriel J. E.
van der Schaaf, Irene C.
Vergouwen, Mervyn D. I.
Funding for this research was provided by:
Hartstichting (2018T076, CVON2015-08 ERASE)
Article History
Received: 5 July 2023
Revised: 6 September 2023
Accepted: 18 September 2023
First Online: 18 December 2023
Declarations
:
: The scientific guarantor of this publication is Mervyn D. I. Vergouwen.
: The authors of this manuscript declare relationships with the following companies: Mervyn D. I. Vergouwen received grant support from Bayer (investigator-initiated research). This company produces GADOVIST®, a contrast agent to perform vessel wall imaging. Bayer had no role in the design and conduct of the study. All other authors had no relevant conflicts of interest.
: Two of the authors, Laura T. van der Kamp and Irene C. van der Schaaf, have significant statistical expertise.
: Written informed consent was waived by the Institutional Review Board.
: This study followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline. The protocol of the study was approved by the Institutional Review Board of the UMC Utrecht. This analysis of existing data from cohorts of patients did not require formal approval from an ethics committee, according to the accredited Medical Research Ethics Committee NedMec (REC number: 21- 145). The individual institutions received approval for retrospective review of the imaging and clinical data, with waiver of consent because data were de-identified.
: Some study subjects or cohorts have been previously reported in Stroke 2020 (129 patients), AJNR 2018 (57 patients), and AJNR 2019 (29 patients). We included data of 455 patients from 12 centres. In total, data of 176 patients from 3 centres were previously published. This is outlined in eTable InternalRef removed, which also includes references to the papers of the 3 monocentre studies. The current study differs from the 3 previous studies: first, this was a multicentre study instead of a monocentre study. Second, we used uniform definitions across all participating centres. Third, we updated the available data which increased the follow-up duration of the previously published patients.
: • retrospective• observational• multicentre study