Lugenbiel, Patrick
Govorov, Katharina
Syren, Pascal
Rahm, Ann-Kathrin
Wieder, Teresa
Wunsch, Maximilian
Weiberg, Nadine
Manolova, Emili
Gramlich, Dominik
Rivinius, Rasmus
Finke, Daniel
Lehmann, Lorenz H.
Schweizer, Patrick A.
Frank, Derk
El Tahry, Fadwa A.
Bruehl, Claus
Heimberger, Tanja
Sandke, Steffi
Weis, Tanja
Most, Patrick
Schmack, Bastian
Ruhparwar, Arjang
Karck, Matthias
Frey, Norbert
Katus, Hugo A.
Thomas, Dierk http://orcid.org/0000-0002-5687-7843
Funding for this research was provided by:
University of Heidelberg, Faculty of Medicine (Postdoctoral Fellowships, Postdoctoral Fellowship)
Deutsche Gesellschaft für Kardiologie-Herz und Kreislaufforschung. (Fellowship, Fellowship, Otto-Hess-Promotionsstipendium)
Ernst und Berta Grimmke Stiftung
Elisabeth und Rudolf-Hirsch Stiftung für Medizinische Forschung
Deutsche Stiftung für Herzforschung (F/08/14, Fellowship, Kaltenbach-Promotionsstipendium, Kaltenbach-Promotionsstipendium, Kaltenbach-Promotionsstipendium)
German Internal Medicine Society (Clinician-Scientist-Program)
Joachim Siebeneicher Foundation
Deutsche Forschungsgemeinschaft (SCHW 1611/-1, TH 1120/7-1, TH 1120/8-1)
Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg (Sonderlinie Medizin)
Heidelberg Research Center for Molecular Medicine (Senior Career Fellowship)
Department of Cardiology, University of Heidelberg (Cardiology Career Program, Cardiology Career Program)
Article History
Received: 23 November 2020
Accepted: 18 February 2021
First Online: 25 February 2021
Declarations
:
: P.L. reports receiving lecture fees from Bayer Vital and Pfizer Pharma and educational support from Boston Scientific and Johnson & Johnson. A.K.R. reports educational support from Boston Scientific, Johnson & Johnson, Abbott and Medtronic. D.T. reports receiving lecture fees/honoraria from Bayer Vital, Boehringer Ingelheim Pharma, Bristol-Myers Squibb, Daiichi Sankyo, Medtronic, Pfizer Pharma, Sanofi-Aventis, St. Jude Medical and ZOLL CMS. The remaining authors have reported that they have no relationships relevant to the content of this paper to disclose.
: Human cardiac tissue samples were obtained from HF patients in accordance with the Declaration of Helsinki and with the regulations of the tissue bank of the National Center for Tumor Diseases (NCT, Heidelberg, Germany), following approval of the Ethics Committee of Heidelberg University (Heidelberg, Germany) (institutional approval number S-390/2011). Heart tissue samples from SR patients with preserved left ventricular function were acquired in accordance with the Declaration of Helsinki following approval of the Ethics Committee of Heidelberg University (Heidelberg, Germany) (institutional approval number S295/2018). Written informed consent was obtained from all patients. Animal experiments in this study have been carried out in accordance with the Guide for the Care and Use of Laboratory Animals as adopted and promulgated by the U.S. National Institutes of Health (NIH publication No. 85–23, revised 1985), and the current version of the German Law on the Protection of Animals was followed. The investigation conforms to the Directive 2010/63/EU of the European Parliament. Cardiac tissue acquisition from pigs 7 days (ethics approval number G-106/10) or 14 days (ethics approval number G-165/12) after the initiation of atrial burst pacing and from control pigs not subjected to burst pacing was approved be the Animal Welfare Committee of the Regierungspräsidium Karlsruhe (Karlsruhe, Germany). Experiments involving mouse cardiomyocytes were approved be the Animal Welfare Committee of the Regierungspräsidium Karlsruhe (ethics approval number T-44/18).