te Lintel Hekkert, Maaike
Newton, Gary
Chapman, Kathryn
Aqil, Rehan
Downham, Robert
Yan, Robert
Merkus, Daphne
Whitlock, Gavin
Lane, Charlotte A. L.
Cawkill, Darren
Perrior, Trevor
Duncker, Dirk J. http://orcid.org/0000-0003-2836-2241
Schneider, Michael D. http://orcid.org/0000-0001-9645-1938
Article History
Received: 4 March 2021
Accepted: 19 April 2021
First Online: 20 May 2021
Declarations
:
: The authors declare that they have no conflict of interest.
: Pig studies were performed in accordance with the “Guiding Principles in the Care and Use of Laboratory Animals” as approved by the Council of the American Physiological Society, and with approval of the Animal Care Committee of the Netherlands (AVD1010020181665). Early PK studies were performed in rats by Saretius (Reading, UK), in accordance with the UK Animals (Scientific Procedures) Act 1986 and the terms of Licence 70/8420 and with approval of the University of Reading Local Ethical Review Process.