Adams, Jason W.
Alosco, Michael L.
Mez, Jesse
Alvarez, Victor E.
Huber, Bertrand R.
Tripodis, Yorghos
Adler, Charles H.
Kubilius, Carol
Cormier, Kerry A.
Mathais, Rebecca
Nicks, Raymond
Kelley, Hunter J.
Saltiel, Nicole
Uretsky, Madeline
Nair, Evan
Aytan, Nurgul
Cherry, Jonathan D.
Nowinski, Christopher J.
Kowall, Neil W.
Goldstein, Lee E.
Dwyer, Brigid
Katz, Douglas I.
Cantu, Robert C.
Stern, Robert A.
McKee, Ann C.
Stein, Thor D. http://orcid.org/0000-0001-6954-4477
Funding for this research was provided by:
U.S. Department of Veterans Affairs (I01-CX001038, BX002466)
National Institute on Aging (RF1AG054156, R56AG057768, RF1AG057768, K23AG046377, P30AG13846)
National Institute of Neurological Disorders and Stroke (U54NS115266, U01NS086659, K23NS102399)
Alzheimer's Association (NIRG-305779, NIRG-362697)
U.S. Department of Defense (PRARP #13267017)
Article History
Received: 19 May 2020
Revised: 26 July 2020
Accepted: 1 August 2020
First Online: 17 September 2020
Compliance with ethical standards
:
: Michael L. Alosco has received honorarium as a Scientific Advisor for Corino Therapeutics, Inc. Dr Goldstein is a paid consultant to Johnson & Johnson, Janssen Research & Development LLC, and Rebiscan Inc, and has received funding from the WWE (World Wrestling Entertainment) and Ivivi Health Sciences. Dr Stern has received research funding from Avid Radiopharmaceuticals Inc, is a member of the Mackey-White Committee of the National Football League Players Association, is a paid consultant to Biogen and Eli Lilly, receives royalties for published neuropsychological tests from Psychological Assessment Resources Inc, and is a member of the Board of Directors of King-Devick Technologies. Dr Cantu is a paid consultant to the National Football League Head Neck and Spine Committee, a vice president and chair of the scientific advisory committee of the National Operating Committee on Standards for Athletic Equipment, and a consultant to the Concussion Legacy Foundation; he also receives royalties from Houghton Mifflin Harcourt and compensation for expert legal opinion to the National Collegiate Athletic Association and National Hockey League and is a member of the Mackey-White Committee of the National Football League Players Association. Dr McKee is a member of the Mackey-White Committee of the National Football League Players Association and reports receiving grants from the National Institutes of Health and Department of Veteran Affairs. Dr Alosco reported grants from National Institutes of Health/National Institute of Neurological Disorders and Stroke during the conduct of the study. Dr Katz reported grants from Boston University School of Medicine Department of Neurology during the conduct of the study. Dr Stern reported grants from the National Institutes of Health during the conduct of the study; personal fees from Biogen and Eli Lilly outside the submitted work; membership on the board of directors for King-Devick Technologies, with stock options; and royalties for published neuropsychological tests from Psychological Assessment Resources Inc. Dr Mez reported grants from the National Institutes of Health, Department of Defense, Alzheimer’s Association, and Concussion Legacy Foundation during the conduct of the study. No other disclosures were reported.
: The study was performed in accordance with the ethical standards established by the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Institutional review board approval was granted from the Boston University Medical Center (BUMC) and the Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA. The BUMC IRB also granted approval for postmortem clinical record review, neuropathological evaluation, and clinical interviews with donor family members.
: Written consent for brain donation and research participation was provided by donor next-of-kin.
: Not applicable.
: The views, opinions, and/or findings contained in this article are those of the authors and should not be construed as an official Veterans Affairs or Department of Defense position, policy or decision, unless so designated by other official documentation.