Funding for this research was provided by:
Fondation Vaincre Alzheimer (# FR18-035)
Received: 9 June 2020
Revised: 3 September 2020
Accepted: 1 October 2020
First Online: 20 October 2020
Compliance with ethical standards
: Authors declare no conflict of interest.
: All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted. In vivo experiments were performed in accordance with the guidelines established by the European community council (Directive of November 24th, 1986), and approved by Nice university Animal care and use Committee, and the National Council on animal care of the Ministry of Health (Project n°: APAFIS#20495-201904231352370). All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical studies. Brain samples were obtained from the Brain Bank “NeuroCEB” run by a consortium of Patients Associations: ARSEP (association for research on multiple sclerosis), CSC (cerebellar ataxias), and France Parkinson. The consents were signed by the patients themselves or their next of kin in their name, in accordance with the French Bioethical (agreement AC-2013-1887). Cases were anonymized, but information was provided regarding sex, age at death, and neuropathology (Suppl.Table 1, online resource).
: Informed consent for tissue donation for research is obtained by the brain banks under their approval procedures.