Shi, Yang
Murzin, Alexey G.
Falcon, Benjamin
Epstein, Alexander
Machin, Jonathan
Tempest, Paul
Newell, Kathy L.
Vidal, Ruben
Garringer, Holly J.
Sahara, Naruhiko
Higuchi, Makoto
Ghetti, Bernardino
Jang, Ming-Kuei
Scheres, Sjors H. W.
Goedert, Michel
Funding for this research was provided by:
Medical Research Council (MC_UP_A025_1013, MC_U105184291)
Foundation for the National Institutes of Health (P30-AG010133, U01-NS110437, U01-NS110437)
Innovative Medicines Initiative (116060)
Japan Agency for Medical Research and Development (JP20dm0207072)
Article History
Received: 14 December 2020
Revised: 4 March 2021
Accepted: 4 March 2021
First Online: 16 March 2021
Change Date: 8 April 2021
Change Type: Correction
Change Details: A Correction to this paper has been published:
Change Details: https://doi.org/10.1007/s00401-021-02303-5
Declarations
:
: M.H. holds a patent related to APN-1607. P.T., M.H. and M.-K.Y. are equity holders in APRINOIA. The other authors declare no competing financial interests.
: Cryo-EM maps have been deposited in the Electron Microscopy Data Bank (EMDB) under accession numbers EMD-12551 for +APN-1607 PHF, EMD-12552 for +APN-1607 SF, EMD-12553 for PHF of PCA case, EMD-12549 and EMD-12550 for PHF and SF of PART case 3, respectively. Refined atomic models have been deposited in the Protein Data Bank (PDB) under accession numbers 7NRV for + APN-1607 PHF, 7NRX for + APN-1607 SF, 7NRQ, 7NRS and 7NRT for PHF, SF conformation 1 and SF conformation 2 of PART case 3, respectively. Whole-exome sequencing data have been deposited in the National Institute on Aging Alzheimer’s Disease Data Storage Site (NIAGADS; ExternalRef removed), under accession number NG00101.