Funding for this research was provided by:
Foundation Neurociencias y Envejecimiento
Received: 25 October 2017
Revised: 16 February 2018
Accepted: 17 February 2018
First Online: 20 March 2018
Compliance with ethical standards
: The study complies with the Declaration of Helsinki. Local ethics committees approved the EDIS study.
: Maria Jose Catalan has received honoraria for consulting, advisory services, speaking services and research from AbbVie Laboratories and Merz. Antonio Molina-Arjona declares he has no conflict of interest. Pablo Mir has received honoraria for lecturing or advisory boards from AbbVie, UCB, Allergan, and Merz, and research grants from the Ministerio de Economía y Competitividad de España [SAF2007-60700], Instituto de Salud Carlos III [PI10/01674, CP08/00174, PI13/01461], Consejería de Economía, Innovación, Ciencia y Empleo de la Junta de Andalucía [CVI-02526, CTS-7685], Consejería de Salud y Bienestar Social de la Junta de Andalucía [PI-0377/2007, PI-0741/2010, PI-0437-2012], Sociedad Andaluza de Neurología, the Jacques and Gloria Gossweiler Foundation, and the Fundación Alicia Koplowitz. Esther Cubo has received travel grant to meetings from Abbvie and Allergan; speaker honorarium from Abbvie and UCB. Jose Matias Arbelo has received honoraria for educational presentations or clinical studies participation by Abbvie, UCB Pharma and Italfarmaco. Pablo Martinez-Martin has received honorarium from Editorial Viguera and Movement Disorder Society for lecturing in courses; from AbbVie for speaking in experts’ meetings and for participating in the Advisory Board of an epidemiological study. Grant: from the International Parkinson and Movement Disorder Society for the Pilot Study of the MDS-Non-Motor Symptoms Scale.
: All patients and caregivers provided written informed consent.