Funding for this research was provided by:
Efficacy and Mechanism Evaluation Programme (11/30/11)
Received: 19 January 2018
Revised: 7 May 2018
Accepted: 9 May 2018
First Online: 30 May 2018
Compliance with ethical standards
: On behalf of all authors, the corresponding author states that there are no relevant conflicts of interest.
: The MS-SMART study was approved by the Scotland ‘A’ Research Ethics Committee (reference 13/SS/0007), and therefore, complies with the standards laid down in the 1964 Declaration of Helsinki and later amendments. All patients gave written informed consent.