Turner, Benjamin
Cree, Bruce A. C.
Kappos, Ludwig
Montalban, Xavier
Papeix, Caroline
Wolinsky, Jerry S.
Buffels, Regine
Fiore, Damian
Garren, Hideki
Han, Jian
Hauser, Stephen L.
Funding for this research was provided by:
F. Hoffman-La Roche Ltd
Article History
Received: 7 December 2018
Revised: 11 February 2019
Accepted: 14 February 2019
First Online: 28 February 2019
Compliance with ethical standards
:
: B. Turner has received honoraria, travel grants and been a member of advisory boards for Biogen, Merck Serono, Novartis, Sanofi Genzyme, and Roche. C. Papeix has received speaking honoraria and travel expense reimbursement for participation in scientific meetings, and has participated in advisory boards in the past years with Biogen, MedDay, Merck Serono, Novartis, Roche, and Sanofi Genzyme. B. Cree has received personal compensation for consulting from AbbVie, Akili, Biogen, EMD Serono, GeNeuro, Novartis, and Sanofi Genzyme. L. Kappos’s institution, the University Hospital Basel, has received research support and payments that were used exclusively for research support for Prof. Kappos’s activities as principal investigator and member or chair of planning and steering committees or advisory boards in trials sponsored by Actelion, Addex, Almirall, Bayer HealthCare Pharmaceuticals, CSL Behring, Genentech, Inc., GeNeuro SA, Genzyme, Merck Serono, Mitsubishi Pharma, Novartis, Octapharma, Ono Pharma, Pfizer, Receptos, F. Hoffmann-La Roche Ltd, Sanofi, Santhera, Siemens, Teva, UCB, and XenoPort; license fees for Neurostatus products; and research grants from the Swiss MS Society, the Swiss National Research Foundation, the European Union, the Gianni Rubatto Foundation, the Novartis Research Foundation and the Roche Research Foundation. X. Montalban has received speaking honoraria and travel expense reimbursement for participation in scientific meetings, has been a steering committee member of clinical trials or participated in advisory boards of clinical trials in the past years with Actelion, Almirall, Bayer, Biogen, Genzyme, Merck, Novartis, Octapharma, Receptos, F. Hoffmann-La Roche Ltd, Sanofi, Teva, and Trophos. J.S. Wolinsky has served on advisory boards, data monitoring or steering committees, has consulting agreements, or received speaker honoraria from the following entities: AbbVie, AcademicCME, Actelion, ACTRIMS, Alkermes, Bayer HealthCare, Biogen, Bionest, Celgene, Clene Nanomedicine, CMSC, ECTRIMS, EMS Serono, Forward Pharma A/S, France Foundation, GeNeuro, MA’s Communications, Masters MS, MedDay Pharmaceuticals, McDonnell Boehnen Hulbert & Berghoff, Novartis Pharmaceuticals, Otsuka, PlatformQ Health Education, PRIME, PTC Therapeutics, Roche Genentech, Sanofi Genzyme, Strategic Consultants International, Takeda, Teva Pharmaceuticals, and WebMD; royalties are received for out-licensed monoclonal antibodies through UTHealth from Millipore Corporation. R. Buffels is an employee of F. Hoffmann-La Roche Ltd. H. Garren is an employee of Genentech, Inc., and a shareholder of F. Hoffmann-La Roche Ltd. D. Fiore is an employee of Genentech, Inc., and a shareholder of F. Hoffmann-La Roche Ltd. J. Han is an employee of Genentech, Inc. S.L. Hauser serves on the board of trustees for Neurona and on scientific advisory boards for Annexon, Symbiotix, Bionure, Alector, and Molecular Stethoscope; he has also received travel reimbursement from F. Hoffmann-La Roche Ltd for CD20-related meetings and presentations.
: This trial was conducted in accordance with the International Conference on Harmonisation guidelines for Good Clinical Practice and the Declaration of Helsinki.
: All patients provided written informed consent.