Received: 27 May 2021
Revised: 24 August 2021
Accepted: 7 September 2021
First Online: 27 September 2021
: All procedures performed in studies involving human participants were in accordance with the ethical standards of the HREC of <i>Centro Hospitalar e Universitário de Coimbra</i> (CHUC) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
: Informed consent was obtained from all individual participants included in the study.
: The authors declare no competing interests.