MacNeil, Ian A.
Burns, David J.
Rich, Benjamin E.
Soltani, Sajjad M.
Kharbush, Samantha
Osterhaus, Nicole G.
Sullivan, Brian F.
Hawkins, Douglas M.
Pietruska, Jodie R.
Laing, Lance G. http://orcid.org/0000-0003-4593-0685
Article History
Received: 12 October 2019
Accepted: 1 February 2020
First Online: 8 February 2020
Compliance with ethical standards
:
: IAM, DJB, BER, SMS, SK, NGO, BFS, and LGL are all employed by and/or have ownership interest in Celcuity, Inc. LGL and BFS are inventors of patents assigned to Celcuity. JRP and DMH are compensated for their contributions on this work.
: Breast tumor specimens were collected from sites that require Institutional Review Board approval to supply human tissue specimens as well as from sites that have pre-established tissue acquisition programs that obtain informed consent for provision of patient specimens independent of Celcuity.
: Healthy and tumor specimens were obtained from excess resected human breast tissue from women over 18 years of age undergoing standard-of care therapeutic surgery and histological diagnosis. Breast tumor specimens were collected from sites with Institutional Review Board (IRB) approval to supply human tissue specimens as well as from sites that have pre-established tissue acquisition programs that obtain informed consent for provision of patient specimens independent of Celcuity. Human tissues and supporting information were de-identified prior to delivery to Celcuity. Advarra IRB (Columbia, MD) determined that this research did not involve human subjects as defined under 45 CFR 46.102(f) and issued a written IRB exemption. The mouse study protocol under which this research was performed was reviewed and approved by the Institutional Animal Care and Use Committee of the University of Minnesota. All animal studies were performed according to the guidelines of the Institutional Animal Care and Use Committee of the University of Minnesota.
: All data generated or analyzed during this study are included in this article and its supplementary information files.