Funding for this research was provided by:
National Institutes of Health (GM094575)
Welch Foundation (I-1505)
Received: 18 October 2017
Accepted: 24 September 2018
First Online: 6 October 2018
Compliance with ethical standards
: The authors declare that they have no competing interests.
: This article does not contain any studies with human participants performed by any of the authors. All applicable international, national, and institutional guidelines for the care and use of animals were followed.
: See the Supplemental Information for the details of our protocols. Major scripts used in this projects and intermediate results are made available at ExternalRef removed.