Nishimura, Ryu
Shirasaki, Tomoaki
Tsuchiya, Kiichiro http://orcid.org/0000-0002-1977-8707
Miyake, Yoshihide
Watanabe, Yusuke
Hibiya, Shuji
Watanabe, Sho
Nakamura, Tetsuya
Watanabe, Mamoru
Funding for this research was provided by:
Japanese Ministry of Education, Culture, Sports, Science and Technology (24590935, 25114703, 25130704, 26221307, 15H04808, 16H06770, 17H06654, 17K15930, 17K19513)
Japan Foundation for Applied Enzymology
Japanese Ministry of Health, Labor and Welfare (14526073)
Japan Agency for Medical Research and Development (15Ack0106017h0002, 16ck0106017h0003, 16ek0109456h0003)
Research Grant of the Princess Takamatsu Cancer Research Fund
Naoki Tsuchida Research Grant
Article History
Received: 7 September 2018
Accepted: 19 December 2018
First Online: 1 January 2019
Compliance with ethical standards
:
: YM and YW are employed by Kaken Pharmaceutical Co., Ltd. KT has received research funding (collaborative research) provided by Kaken Pharmaceutical Co., Ltd.
: MW, TN and KT designed the experiments and acquired data. TS and SH established inflammatory stimulation of the organoids. RN and SW assessed the effect of KAG-308 on the organoids. YM and YW assessed the effect of KAG-308 on DSS colitis model in mice. KT and MW coordinated the projects and drafted the manuscript.