Devos, David
,
Cabantchik, Z. Ioav
Moreau, Caroline
Danel, Véronique
Mahoney-Sanchez, Laura
Bouchaoui, Hind
Gouel, Flore
Rolland, Anne-Sophie
Duce, James A.
Devedjian, Jean-Christophe
Funding for this research was provided by:
H2020 European Institute of Innovation and Technology (633190)
Ministère de l'Enseignement Supérieur et de la Recherche (FAIR-ALSII)
Article History
Received: 21 November 2019
Accepted: 28 December 2019
First Online: 7 January 2020
Compliance with ethical standards
:
: The authors have no financial disclosures to make or potential conflicts of interest to report in relation to this study. The paper is referring to four academic studies including two translational studies already published : FAIRPARK-I (Efficacy and Safety of the Iron Chelator Deferiprone in Parkinson's Disease Protocol ID: 2008-006842-25; ClinicalTrials.gov: NCT00943748) and SAFEFAIR-ALS (Efficacy and Safety of the Iron Chelator Deferiprone in Amyotrophic lateral sclerosis Protocol ID: 2013-001228-21; ClinicalTrials.gov: NCT02164253) and two in progress : FAIRPARK-II (with the French NS-Park network, which is funded by a grant from the European Commission Horizon 2020 PHC13 2014-2015 (N° 633190): “Conservative iron chelation as a disease-modifying strategy in Parkinson’s disease: a multicentre, parallel-group, placebo-controlled, randomized clinical trial of deferiprone” Protocol ID: 2015_22; Clinical trial: NCT02655315 http://fairpark2.eu) and FAIRALS-II (Conservative Iron Chelation by Deferiprone as a Disease-modifying Strategy for Amyotrophic Lateral Sclerosis using a Multicentre, Parallel-group, Placebo-controlled, Randomized Clinical Trial on 240 patients. Protocol ID: 2017-003763-35; ClinicalTrials.gov: NCT03293069 funded by the French Ministry of Health, PHRC-N2017). ApoPharma provided deferiprone and advices on the molecule for the four investigator drive studies. Caroline Moreau has received grants from the France Parkinson charity. She has received various honoraria from pharmaceutical companies for consultancy and lectures on Parkinson’s disease at symposia such as Aguettant, Abbvie, Medtronic, Novartis. James Duce has received research funding from Alzheimer’s Society, Alzheimer’s Research UK, European Commission, Parkinson’s UK and NHMRC. He serves as a scientific advisor on the FAIRPARK II but has no financial disclosures. Ioav Cabantchik consults for Aferrix Ltd (Israel) and Hinoman (Ltd) Israel and has been an invited speaker in meetings organized by Apopharma (Canada) for which he received lecturer honoraria. David Devos has received PHRC grants from the French Ministry of Health and research funding from the ARSLA charity, France Parkinson charity, Credit Agricole Fundation. He has led two pilot investigator driven studies with DFP provided for free by ApoPharma (FAIRPARK-I and SAFE-FAIR ALS-I). He is leading two large investigator driven studies with DFP provided for free by ApoPharma (FAIRPARK-II and FAIR ALS-II). He served on advisory boards, served as a consultant and given lectures for pharmaceutical companies such as Orkyn, Everpharma, Abbvie, Boston Scientific, Lundbeck. Jean-Christophe Devedjian, Véronique Danel, Laura Mahoney-Sanchez, Hind Bouchaoui, Anne-Sophie Rolland have nothing to declare.