Janssen, C. A. http://orcid.org/0000-0001-6359-916X
Oude Voshaar, M. A. H.
ten Klooster, P. M.
Vonkeman, H. E.
van de Laar, M. A. F. J.
Funding for this research was provided by:
ZonMw (836031015)
Swedish Orphan Biovitrum AB (n/a)
Article History
Received: 6 February 2019
Revised: 9 April 2019
Accepted: 15 April 2019
First Online: 27 April 2019
Compliance with ethical standards
:
: Unrestricted educational grants and non-financial support from Swedish Orphan Biovitrum AB during the conduct of the study, and an unrestricted educational grant from GrĂ¼nenthal B.V. outside the submitted work, were declared by C.A. Janssen, M.A.H. Oude Voshaar, and M.A.F.J. van de Laar. Also, M.A.F.J van de Laar reports consultancy work/speaking for GrĂ¼nenthal B.V. and Swedish Orphan Biovitrum AB. The other authors declare to have no conflicts of interest.
: The study was approved by an independent ethics committee (METC Twente, Enschede, the Netherlands), and by the institutional review board of each participating center. It has therefore been performed in accordance with ethical standard laid down in the 1964 Declaration of Helsinki and its later amendments, and the Dutch Medical Research Involving Human Subjects Act. All patients provided written informed consent prior to study initiation<b>.</b>