Funding for this research was provided by:
Insmed
Article History
Received: 23 May 2018
Accepted: 21 June 2018
First Online: 27 June 2018
Compliance with ethical standards
:
: Miss Axson has nothing to disclose. Dr. Bloom has nothing to disclose. Dr. Quint reports grants and personal fees from Insmed, during the conduct of the study; grants from MRC, grants from Wellcome Trust, grants from British Lung Foundation, grants and personal fees from GSK, grants and personal fees from Boehringer Ingelheim, grants from Royal College of Physicians, personal fees from Chiesi, personal fees from Teva, outside the submitted work.
: The protocol for this research was approved by the Independent Scientific Advisory Committee (ISAC) for MHRA Database Research (protocol number 17_113R) and the approved protocol was made available to the journal and reviewers during peer review. Following initial approval, an amendment was also submitted to ISAC and approved (protocol 17_113RA), expanding the analysis to more respiratory diseases. Generic ethical approval for observational research using the CPRD with approval from ISAC has been granted by a Health Research Authority (HRA) Research Ethics Committee (East Midlands – Derby, REC reference number 05/MRE04/87).
: No patients were involved in the design or analyses for this study.