Asanuma, Hiroshi
Chung, Hyemoon
Ito, Shin
Min, Kyung-Duk
Ihara, Madoka
Takahama, Hiroko
Funayama, Marina
Imazu, Miki
Fukuda, Hiroki
Ogai, Akiko
Asano, Yoshihiro
Minamino, Tetsuo
Takashima, Seiji
Morita, Toshisuke
Sugimachi, Masaru
Asakura, Masanori
Kitakaze, Masafumi
Funding for this research was provided by:
The Ministry of Health, Labor, and Welfare-Japan
The Ministry of Education, Culture, Sports, Science and Technology-Japan
Japan Agency for Medical Research and Development
The Japan Heart Foundation
The Japan Cardiovascular Research Foundation
The collaborative research with Kureha Corporation and Mitsubishi Tanabe Pharma Corporation
Article History
First Online: 23 March 2019
Compliance with Ethical Standards
: All procedures complied with the Guide for the Care and Use of Laboratory Animals published by the US National Institutes of Health (the 8th Edition, NRC 2011) and were approved by the National Cerebral and Cardiovascular Center Committee for Laboratory Animal Use.
: T. Morita reports grants from LSI Medience, AMNOS Company, UNITIKA, and TED Pharmaceutical Co. M. Asakura reports grants from the government during the conduct of the study, personal fees and non-financial support from Pfizer, and personal fees from Boehringer-Ingerheim, Mitsubishi-Tanabe, Kowa, and Takeda. M. Kitakaze reports grants from the Japanese government;grants from Japan Heart Foundation; grants from Japan Cardiovascular Research Foundation; grants and personal fees from Takeda, Asteras, Sanofi, Pfizer, Novartis, Boehringer-Ingerheim, Mitsubishi-Tanabe, Kyowa-Hakko-Kirin, Abott, and Otsuka; personal fees from Daiichi-Sankyo, Ono, Bayer, from Kowa, Dainihon-Sumitomo, Sawai, MSD, Calpis, Shionogi, AstraZeneca, Asahikasei, Novo Nordisk, Fuji-film RI, and Japan Medical Data; and grants from Nihon Kohden.
: All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted. This article does not contain any studies with human participants performed by any of the authors.