de Vries Schultink, Aurelia H. M.
Doornbos, Robert P.
Bakker, Alexander B. H.
Bol, Kees
Throsby, Mark
Geuijen, Cecile
Maussang, David
Schellens, Jan H. M.
Beijnen, Jos H.
Huitema, Alwin D. R.
Funding for this research was provided by:
Merus N.V.
Article History
Received: 19 January 2018
Accepted: 19 March 2018
First Online: 5 May 2018
Compliance with ethical standards
:
: Robert Doornbos, Alexander Bakker, Kees Bol, Mark Throsby, Cecile Geuijen and David Maussang are employees of Merus N.V. Aurelia de Vries Schultink, Jan Schellens, Jos Beijnen, and Alwin Huitema declare that they have no conflict of interest.
: This article does not contain any studies with human participants performed by any of the authors. The experiments in cynomolgus monkeys were conducted at Charles River Laboratories Edinburg (preclinical services). All procedures were performed in accordance with the UK Animals (Scientific Procedures) Act, 1986, approved by institutional ethical review committees and conducted under the authority of the Project License. Mouse xenograft studies were performed by Charles River Discovery Services North Carolina, USA and the experimental protocol was approved by the site’s Institutional Animal Care and Use Committee. The facility is accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC).