Sandhu, Shahneen
McNeil, Catriona M.
LoRusso, Patricia
Patel, Manish R.
Kabbarah, Omar
Li, Chunze
Sanabria, Sandra
Flanagan, W. Michael
Yeh, Ru-Fang
Brunstein, Flavia
Nazzal, Denise
Hicks, Rodney
Lemahieu, Vanessa
Meng, Raymond
Hamid, Omid
Infante, Jeffrey R.
Article History
Received: 24 May 2019
Accepted: 2 July 2019
First Online: 5 August 2019
Compliance with ethical standards
:
: SS: Consultant/advisory board member for Roche-Genentech, Novartis, Astra-Zeneca, Bristol Meyers Squibb, Merck Sharp and Dolme and Amgen. Research grant funding from Amgen, Bristol Meyers Squibb, Merck Sharp and Dolme, Merck and Genentech.CM: None.PL: None.MP: Speakers bureau/advisory boards for Pfizer, Exelixis, Pharmacyclics, Celgene, and Bayer.OK: Employee of Genentech, Inc., shareholder of F. Hoffmann La Roche, Ltd.CL: Employee of Genentech, Inc., shareholder of F. Hoffmann La Roche, Ltd.WF: Employee of Genentech, Inc., shareholder of F. Hoffmann La Roche, Ltd.RY: Employee of Genentech, Inc., shareholder of F. Hoffmann La Roche, Ltd.FB: Employee of Genentech, Inc., shareholder of F. Hoffmann La Roche, Ltd.RJH: Advisory board member and stockholder of Telix Pharmaceuticals. Consultant for Endocyte. Research grant funding from Ipsen and ITG.DN: Employee of Genentech, Inc., shareholder of F. Hoffmann La Roche, Ltd.VL: Employee of Genentech, Inc., shareholder of F. Hoffmann La Roche, Ltd.RM: Employee of Genentech, Inc., shareholder of F. Hoffmann La Roche, Ltd.OH: Consulting for Roche, Amgen, Novartis, BMS, Merck. Speaker for Genentech, BMS, Novartis, Amgen, Sanofi, Array. Contracted research for institution from Roche-Genentech, Amgen, Arcus, Astellas, AstraZeneca, BMS, Celldex, Cytomx, GSK, Immunocore, Incyte, Iovance, Merck, Merck Serono, MedImmune, NextCure, Novartis, Parker, Pfizer, Polynoma, Regeneron.JI: Consulting for Armo Biosciences, Bio Med Valley Discoveries. Employee of Janssen Pharmaceuticals.
: This study was conducted at 6 institutions in the United States and Australia in accordance with the International Conference on Harmonization E6 Guidelines and the principles of Good Clinical Practice. The study was approved by regulatory and ethics committees at each institution and was registered at Clinicaltrials.gov, NCT01522664. The study was sponsored by Genentech, Inc.
: Informed consent was obtained from all individual participants included in the study.