Lloyd, A. J.
Willis, N. D.
Wilson, T.
Zubair, H.
Chambers, E.
Garcia-Perez, I.
Xie, L.
Tailliart, K.
Beckmann, M.
Mathers, J. C.
Draper, J.
Funding for this research was provided by:
Medical Research Council (MR/ J010308/1)
Article History
Received: 26 December 2018
Accepted: 19 April 2019
First Online: 2 May 2019
Compliance with ethical standards
:
: The authors have no conflicts of interest to declare.
: The manuscript has not been submitted to more than one journal for simultaneous consideration. All participants gave written informed consent. A favorable ethical opinion was obtained following Proportionate Review by the East Midlands—Nottingham 1 National Research Ethics Committee (14/EM/0040). The trial was adopted into the UK Clinical Research Network (CRN) Portfolio (16037) and is registered with International Standard Randomized Controlled Trials Number (ISRCTN), 88921234. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.