Ressler, Julia Maria
Tomasich, Erwin
Hatziioannou, Teresa
Ringl, Helmut
Heller, Gerwin
Silmbrod, Rita
Gottmann, Lynn
Starzer, Angelika Martina
Zila, Nina
Tschandl, Philipp
Hoeller, Christoph
Preusser, Matthias
Berghoff, Anna Sophie
Funding for this research was provided by:
Christian Doppler Forschungsgesellschaft
Bundesministerium für Digitalisierung und Wirtschaftsstandort
Österreichische Nationalstiftung für Forschung, Technologie und Entwicklung
Medical University of Vienna
Article History
Accepted: 2 February 2024
First Online: 24 February 2024
Declarations
:
: Open access funding provided by Medical University of Vienna. This study was supported by the Christian Doppler Research Association, the Austrian Federal Ministry for Digital and Economic Affairs, and the National Foundation for Research, Technology, and Development.
: Julia Maria Ressler received honoraria for lectures from Bristol-Myers Squibb, Roche, Amgen, and Novartis and travel support from Sanofi, Roche, and Bristol-Myers Squibb. Angelika Martina Starzer received honoraria for lectures from AstraZeneca and travel and congress support from PharmaMar, MSD, and Lilly. Christoph Höller reports speaker honoraria from Amgen, BMS, MSD, Novartis, and Roche, participation in advisory boards for Amgen, Astra Zeneca, BMS, Incyte, MSD, Novartis, Pierre Fabre, and Roche, and research funding by Amgen to the institution. Matthias Preusser has received honoraria for lectures, consultation, and advisory board participation from the following for-profit companies: Bayer, Bristol-Myers Squibb, Novartis, Gerson Lehrman Group (GLG), CMC Contrast, GlaxoSmithKline, Mundipharma, Roche, BMJ Journals, MedMedia, Astra Zeneca, AbbVie, Lilly, Medahead, Daiichi Sankyo, Sanofi, Merck Sharp & Dome, Tocagen, Adastra, Gan & Lee Pharmaceuticals, and Servier. Anna Sophie Berghoff has research support from Daiichi Sankyo and Roche, honoraria for lectures, consultation, and advisory board participation from Roche Bristol-Meyers Squibb, Merck, Daiichi Sankyo, AstraZeneca, and CeCaVa, and travel support from Roche, Amgen, and AbbVie. Philipp Tschandl received honoraria from Silverchair, unrestricted grants for education projects from Lilly, and honoraria for lectures from AbbVie, Lilly, FotoFinder, and Novartis. Erwin Tomasich, Teresa Hatziioannou, Helmut Ringl, Gerwin Heller, Rita Silmbrod, Lynn Gottmann, and Nina Zila have no conflicts of interest that are directly relevant to the content of this article.
: This study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Ethics committee of the Medical University of Vienna (Number 1312/2021).
: Written informed consent from the study participants was obtained.
: Not applicable.
: Raw data of DNA methylation analysis are publicly available at the Gene Expression Omnibus database respiratory under the accession number GSE235122. Further data will be shared upon reasonable request to the corresponding author. The relevant data set of the study is included in the article or uploaded as supplementary information. Additional data will be shared upon request by the authors.
: Not applicable.
: JMR: conceptualization, resources, data curation, formal analysis, validation, writing of the original draft. ET: formal analysis, validation, writing. TH: formal analysis, validation. HR: radiological assessment, validation. GW: bioinformatical analysis, visualization, validation, writing. RS: data curation, formal analysis. LG: data curation, formal analysis. AMS: data curation, formal analysis. NZ data curation, formal analysis. PT: resources, formal analysis. CH: resources, validation, supervision. MP: conceptualization, resources, validation, writing, supervision. ASB: conceptualization, resources, formal analysis, validation, writing. All authors read and approved the final manuscript.