Olkus, Alexander
Tomczak, Aurelie
Berger, Anne Katrin
Rauber, Conrad
Puchas, Philip
Wehling, Cyrill
Longerich, Thomas
Mehrabi, Arianeb
Chang, De-Hua
Liermann, Jakob
Schäfer, Sophia
Pfeiffenberger, Jan
Jäger, Dirk
Michl, Patrick
Springfeld, Christoph
Dill, Michael T. http://orcid.org/0000-0002-1926-4204
Funding for this research was provided by:
Deutsche Krebshilfe (70113858)
German Ministry of Research and Education (01ZZ1802, 01ZZ3222E)
Universitätsklinikum Heidelberg
Article History
Accepted: 5 February 2024
First Online: 28 February 2024
Declarations
:
: Open Access funding enabled and organized by Projekt DEAL. A.T. is supported by the German Ministry of Research and Education (01ZZ1802, 01ZZ3222E). M.T.D. is supported by a Max Eder funding grant (70113858) of the German Cancer Aid.
: P. Michl receives speakers honorary by AstraZeneca. Alexander Olkus, Aurelie Tomczak, Anne Katrin Berger, Conrad Rauber, Philip Puchas, Cyrill Wehling, Thomas Longerich, Arianeb Mehrabi, De-Hua Chang, Jakob Liermann, Sophia Schäfer, Jan Pfeiffenberger, Dirk Jäger, Christoph Springfeld and Michael T. Dill declare that they have no conflicts of interest that might be relevant to the contents of this manuscript.
: The LCCH registry study was approved by the local ethics committee of the Heidelberg University Hospital (S-693/2019). Informed consent was obtained from all prospectively enrolled patients. The study was performed in accordance with the Declaration of Helsinki.
: Not applicable.
: Relevant genomic data are provided as Supplementary Material. Additional data are available upon reasonable request.
: Not applicable.
: A.O. and M.T.D. conceived and designed the study. A.O., A.T., T.L. and M.T.D. analysed the data. A.B., T.L., C.S., P.P., C.R., C.W., M.T.D., A.M., D.H.C., J.L., J.P., D.J. and P.M. participated in interdisciplinary tumour board decisions, supervised clinical annotations and provided critical data interpretation. S.S. supervised the clinical cancer registry and provided intellectual input. A.O. and M.T.D. wrote the manuscript. A.B., C.S. and A.T. provided substantial editorial work to the manuscript. All authors have read and provided comments on the manuscript. All authors approved the manuscript and gave their consent for submission and publication.