Funding for this research was provided by:
National Heart, Lung, and Blood Institute (HHSN268201800003I, HHSN268201800004I, HHSN268201800005I, HHSN268201800006I, HHSN268201800007I)
National Institute on Aging (AG0005, T32AG027668, K24AG031155, R01AG063887)
Accepted: 2 August 2021
First Online: 6 September 2021
: Ryan J. Dougherty, Tina D. Hoang, Lenore J. Launer, David R. Jacobs, Jr, and Stephen Sidney declare no conflicts of interest. Kristine Yaffe serves on DSMBs for Eli Lilly and several National Institute on Aging–sponsored studies and is also a member of the Beeson Scientific Advisory Board and the Global Council on Brain Health.
: The CARDIA study and brain MRI ancillary study were approved by the Institutional Review Board (IRB) of each of the participating sites as well as the University of Pennsylvania and University of California, San Francisco. All procedures followed were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. At each examination participants were provided and signed a separate written informed consent for the CARDIA study and the brain MRI ancillary study.