Crespo, Inmaculada http://orcid.org/0000-0003-3086-9762
Pignatelli, Jaime
Kinare, Veena
Méndez-Gómez, Héctor R.
Esgleas, Miriam
Román, María José
Canals, Josep M.
Tole, Shubha
Vicario, Carlos http://orcid.org/0000-0002-7060-0250
Funding for this research was provided by:
Ministerio de Ciencia, Innovación y Universidades (SAF2013-4759R, SAF2016-80419-R, RTI2018-099001-B-100, CIBERNED CB06/05/0065, RETICS-Red de Terapia Celular- RD16/0011/0012, CSIC201320E054)
Comunidad de Madrid (S2011/BMD-2336)
Generalitat de Catalunya (2017SGR-1408)
University Grants Commission
Department of Atomic Energy, Government of India (RTI4003)
Consejo Superior de Investigaciones Cientificas
Article History
Received: 1 December 2021
Accepted: 10 June 2022
First Online: 4 July 2022
Declarations
:
: Not applicable.
: Not applicable.
: The authors declare no competing interests.
: All animal care and handling were carried out in accordance with the European Union guidelines (directive 2010/63/EU) and Spanish legislation (Law 32/2007 and RD 53/2013). The protocols were approved by the Ethics Committees of the Consejo Superior de Investigaciones Científicas (CSIC, Madrid, Spain) and the Comunidad de Madrid (Spain). Some experiments related to the data shown in Fig. InternalRef removed, as well as the Ki67 (at E18.5) and RC2 results, were performed at the Tata Institute of Fundamental Research following animal protocols approved by the Institution’s Animal Ethics Committee and according to the regulations devised by the Committee for the Purpose of Control and Supervision of Experiments on Animals. Animals were administered food and water ad libitum, and they were housed in strictly controlled environmental conditions: 12 h light/dark cycle, 22 °C temperature and 44% humidity. All efforts were made to ameliorate the animal’s suffering.