Article History
Received: 17 December 2019
Accepted: 25 February 2020
First Online: 10 March 2020
Compliance with ethical standards
:
: All authors declare that they have no competing interest.
: This study is a secondary analysis based on publicly available de-identified datasets of the PLCO trial. Primary PLCO trial was approved by the IRBs of all included centers. Details of IRB approval for each center were provided in the original publications of the PLCO trial (Ref [CitationRef removed]) as well as in the clinicaltrials.gov records of the PLCO trial (NCT00002540).
: All participants provided written informed consent prior to inclusion into the PLCO trial.