Funding for this research was provided by:
Instituto de Salud Carlos III (PI13/00134)
European Regional Development Fund (PI13/00134)
First Online: 19 December 2018
Compliance with Ethical Standards
: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Clinical Research Ethics Committee of the Hospital de la Santa Creu i Sant Pau (Barcelona, Spain).
: The authors declare that they have no conflicts of interest.
: Informed consent was obtained from all individual participants included in the study.