Funding for this research was provided by:
Federal Ministry of Education and Research (BMBF), Germany (FKZ: 01EO1002)
Text and Data Mining valid from 2019-01-07
Received: 6 August 2018
Revised: 3 December 2018
Accepted: 28 December 2018
First Online: 7 January 2019
Compliance with Ethical Standards
: The study protocol was approved by the local ethic committee of the Jena University Hospital and registered at the German Clinical Trial Register DRKS00003392. Each patient gave written informed consent.
: The authors declare that they have no conflict of interest.
: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.