Chen, Cheng http://orcid.org/0000-0002-4723-2525
Liao, Yuanxin http://orcid.org/0000-0003-1508-9936
Peng, Guangdun http://orcid.org/0000-0002-8586-0637
Article History
Received: 3 December 2021
Accepted: 6 March 2022
First Online: 19 April 2022
Declarations
: This work was supported in part by National Key R&D Program of China (2018YFA0801402, 2018YFA0107200), the "Strategic Priority Research Program" of the Chinese Academy of Sciences (XDA16020404), Guangdong Basic and Applied Basic Research Foundation (2019B151502054), Frontier Research Program of Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory, 2018GZR110105013), Jiazi Research Innovative Project of Bioland Laboratory (2019GZR110108001), Science and Technology Planning Project of Guangdong Province (2020B1212060052).
: The authors declare that they have no competing interests, and agree to publish this manuscript.
: CNV, copy number variation; CRISPR, clustered regularly interspaced short palindromic repeats; CRISPR BC, CRISPR barcode; FACS, fluorescence-activated cell sorting; FP, fluorescent protein; HSCs, hematopoietic stem cells; InDel, insertion and deletion; IntBC, integration barcode; MF, mosaic fractions; pA, polyA tail; polyloxBC, polylox barcode; SCLT, single-cell lineage tracing; scRNA-seq: single-cell RNA sequencing; SNP, single nucleotide polymorphism; SNVs, single nucleotide variations; TF, transcription factor; UGI, uracil DNA glycosylase inhibitor; UMAP, uniform manifold approximation and projection; UMIs, unique molecular identifiers; UTR, untranslated region.