Naik, Himanshu http://orcid.org/0000-0002-0215-296X
Zhao, Yuan
Forrestal, Fiona
Cleall, Simon
Bockbrader, Howard
Chapel, Sunny
Article History
First Online: 29 March 2021
Declarations
:
: No specific funding was received for the preparation of this article.
: H.N., Y.Z., S.C. (Cleall) and F.F. are employees and shareholders of Biogen. S.C. (Chapel) and H.B. are employees of Ann Arbor Pharmacometrics Group and performed the analyses funded by Biogen. The views and opinions expressed in this article are those of the authors and do not necessarily reflect the views or position of any of their employers.
: All the study protocol was approved by the local ethical committee.
: Written informed consent was obtained from each patient taking part to the study, in compliance with the International Council for Harmonisation (ICH) Good Clinical Practice (GCP) Guideline.
: Not applicable.
: The datasets generated during and/or analyzed from various studies are not publicly available for confidentiality reasons.
: Custom NONMEM and R codes used for model building, simulations and computation/representation of VPC are not publicly available but are available from the corresponding author upon request.
: All authors were involved in planning, executing, data set generation, analysis interpretation and summarization of the analyses.