Djebli, Nassim http://orcid.org/0000-0003-3333-2979
Buchheit, Vincent
Parrott, Neil
Guerini, Elena
Cleary, Yumi
Fowler, Stephen
Frey, Nicolas
Yu, Li
Mercier, François
Phipps, Alex
Meneses-Lorente, Georgina
Funding for this research was provided by:
F. Hoffmann-La Roche Ltd
Article History
Accepted: 17 August 2021
First Online: 8 September 2021
Declarations
:
: The clinical studies reported in this manuscript were funded by F. Hoffmann-La-Roche (formerly Ignyta Inc., a member of the Roche Group). The modeling analyses were also funded by F. Hoffmann-La-Roche. Administrative support was provided by Ashfield Medcomms, an Ashfield Health company, and was funded by F. Hoffmann-La Roche Ltd.
: G.M-L. is an employee of Roche Products Ltd. N.D. E.G. Y.C., and A.P. are employees and stockholders of F. Hoffmann-La Roche Ltd. F.M., V.B., N.P., N.F., and S.F. are employees of Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland. L.Y. is a former employee of the Roche Innovation Center, Little Falls, NJ, USA.
: Qualified researchers may request access to individual patient level data through the clinical study data request platform (ExternalRef removed). Further details on Roche's criteria for eligible studies are available here (ExternalRef removed). For further details on Roche's Global Policy on the Sharing of Clinical Information and how to request access to related clinical study documents, see here (ExternalRef removed).
: Not applicable.
: All authors were involved in interpretation of the data, revising the manuscript critically for important intellectual content, approved the final version, and agree to be accountable for the work. Additionally, the authors contributed as follows: S.F. performed the data analysis; V.B. contributed to the conception and planning of the work that led to the manuscript; N.B. drafted the manuscript content.
: All studies were approved by the relevant ethics committees, and were conducted in accordance with the principles of the Declaration of Helsinki and Good Clinical Practice guidelines.
: All subjects provided written informed consent prior to enrollment in the clinical studies.
: Not applicable.