Song, Xin
Zheng, Minglan
Hu, Heping
Chen, Lei
Wang, Shuzhe
Ding, Zhao
Fu, Guangyi
Sun, Luyao
Zhao, Liyuan
Zhang, Ling
Xu, Bohua
Qiu, Yunliang
Article History
Accepted: 31 January 2024
First Online: 23 February 2024
Declarations
:
: This study was funded by Jiangsu Province New Drug One-Stop Efficient Non-clinical Evaluation Public Service Platform Construction BM2021002.
: Minglan Zheng is an employee of Yangtze River Delta Center for Drug Evaluation and Inspection of NMPA. Heping Hu, Zhao Ding, and Guangyu Fu are employees of Sichuan Huiyu Seacross Pharmaceutical Co., Ltd. Lei Chen, Shuzhe Wang, Ling Zhang, and Bohua Xu are employees of InnoStar Bio-tech Nantong Co., Ltd. Yunliang Qiu is an employee of Shanghai InnorStar Biotech Co., Ltd. The other authors declare no competing interests.
: Xin Song: substantial contributions to the machine learning and interpretation of data for the work; drafting the work manuscript. Minglan Zheng: interpretation of data for the work; reviewing the manuscript. Heping Hu: interpretation of data for the work; reagent HY-088 injection was provided; reviewing the manuscript. Lei Chen: substantial contributions to conduct the machine learning and interpretation of data for the work. Shuzhe Wang: substantial contributions to conduct the machine learning and interpretation of data for the work; participated in research design. Zhao Ding: reviewing the manuscript; reagent HY-088 injection was provided; Guangyi Fu: reviewing the manuscript; reagent HY-088 injection was provided. Luyao Sun: interpretation of data for the work. Liyuan Zhao: interpretation of data for the work. Ling Zhang: substantial contributions to conduct the machine learning and interpretation of data for the work. Bohua Xu: substantial contributions to conduct the machine learning and interpretation of data for the work; interpretation of data for the work; reviewing the manuscript; final approval of the version to be published. Yunliang Qiu: reviewing the manuscript; final approval of the version to be published.
: The data that support the findings of this study are available from the corresponding author upon reasonable request.
: All animal experiments in this study were approved by the Institutional Animal Care and Use Committee of InnoStar Bio-tech Nantong Co., Ltd. Approval numbers: 2021-583 (2021.09.07), IACUC-2022-r-005a (2022.01.06), IACUC-2022-r-104 (2022.02.18), IACUC-2022-r-446 (2022.08.01), and IACUC-2022-r-626 (2022.10.17).
: Not applicable.
: Not applicable.