Li, Ruirui
Shan, Linwei
Yao, Yanan
Peng, Feifei
Jiang, Shanshan
Yang, Dandan
Ling, Guixia
Zhang, Peng http://orcid.org/0000-0002-6881-9800
Funding for this research was provided by:
National Natural Science Foundation of China (81202480, 81302723)
Natural Science Foundation of Liaoning Province (2015020749)
Article History
First Online: 9 August 2020
Compliance with ethical standards
:
: The authors declare that they have no conflict of interest.
: This article contained animal studies; all institutional and national guidelines for the care and use of laboratory animals were followed. The animal studies were permitted by the Animal Ethics Committee of Shenyang Pharmaceutical University (Shenyang, China). Animal studies were conducted according to the “guidelines for the care and use of laboratory.” The living conditions of the animals were appropriate for their species and contribute to their health and comfort. Normally, the housing, feeding, and care of all animals used for biomedical purposes were directed by other scientist trained and experienced in the proper care, handling, and use of the species being studied. The use of animals was proper including the avoidance or minimization of discomfort, distress, and pain when consistent with sound scientific practices. Procedures with animals that might cause more than momentary or slight pain or distress were performed with appropriate sedation, analgesia, or anesthesia. The procedures were not performed on un-anesthetized animals paralyzed by chemical agents. Animals were painlessly euthanized at the end of the procedure. The animal studies were harmless to humans or the environment.
: We certify that this manuscript is original and has not been published and will not be submitted elsewhere for publication while being considered by DDTR. And the study is not split up into several parts to increase the quantity of submissions and submitted to various journals or to one journal over time. No data have been fabricated or manipulated (including images) to support our conclusions. Informed consent was obtained from all individual participants included in the study.