Funding for this research was provided by:
Received: 11 April 2022
Accepted: 13 May 2022
First Online: 3 June 2022
: This study was funded by Roche Medical Department Spain (SL42765). The sponsor also funded the journal’s Rapid Service fee.
: All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.
: All authors made a significant contribution to the work reported, whether in study conception, design, execution, acquisition of data, analysis and interpretation, or in all these areas; all took part in drafting, revising or critically reviewing the article; all gave final approval of the version to be published; all have agreed on the journal to which the article has been submitted; and all agree to be accountable for all aspects of the work.
: This study was funded by Roche Medical Department Spain (SL42765) and supported by NeuroeconSolutions. The funding source had no role in the design, analysis and interpretation of the data, review or approval of the manuscript, and decision to submit for publication. Gustavo Saposnik received unrestricted grants and personal fees from Hoffman La Roche (Canada) and Roche Farma (Spain), and reported being supported by the Heart and Stroke Foundation of Canada Scientist Award following an open peer-reviewed competition. Paola Díaz-Abós, María Brañas-Pampillón, Victoria Sánchez-Menéndez, Rosana Cabello-Moruno and Jorge Maurino are employees of Roche Farma Spain. Ana Camacho, María Terzaghi, and Ignacio Málaga declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
: The study was approved by the ethics committee of Hospital Clínico San Carlos, Madrid, Spain (reference 21/313-E), and performed in accordance with the 1964 Helsinki Declaration and its later amendments. Participants provided written informed consent.
: Qualified researchers may request access to individual patient-level data through the corresponding author. The datasets generated during the analysis of the study are available from the corresponding author on reasonable request.