Funding for this research was provided by:
National Institute of Aging (RF1AG063913)
Received: 10 May 2022
Accepted: 9 June 2022
First Online: 1 July 2022
: This study and the publication cost (Rapid Service Fee and the Open Access fee) are supported by RF1AG063913 from the National Institutes of Health (Bethesda, MD, USA) and Research Award from Eisai, Inc (Nutley, NJ, USA) (WX). The funders had no decisional role in study design, data collection and analysis, interpretation of data, in the writing of the report, decision to publish, or preparation of the manuscript.
: All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.
: Concept and design (PJM, ML, QZ, WX), data extraction (ML, YW, BA), statistical analysis (ML), drafting the manuscript (PJM, ML, WX), and manuscript revision (DRB, AATM, MI).
: Amir Abbas Tahami Monfared, MD, PhD, Michael Irizarry, MD, MPH, and Quanwu Zhang, PhD are employees of Eisai, Inc. Peter Morin, MD, PhD, Mingfei Li, PhD, Ying Wang, Byron Aguilar, PhD, Dan Berlowitz, MD, and Weiming Xia, PhD have nothing to disclose. The authors have declared that no personal, financial, commercial, or academic conflicts of interest exist for the submitted work.
: This study was approved by the Bedford VA Healthcare System Institutional Review Board, and all data were fully de-identified before access. This study was performed in accordance with the Helsinki Declaration of 1964 and its later amendments.
: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request. Approval by the Department of Veterans Affairs is required for data access.