Hobbs, F. D. Richard
Montgomery, Hugh
Padilla, Francisco
Simón-Campos, Jesus Abraham
Kim, Kenneth
Arbetter, Douglas
Padilla, Kelly W.
Reddy, Venkatesh Pilla
Seegobin, Seth
Streicher, Katie
Templeton, Alison
Viani, Rolando M.
Johnsson, Eva
Koh, Gavin C. K. W.
Esser, Mark T.
Funding for this research was provided by:
AstaZeneca
Article History
Received: 25 May 2023
Accepted: 16 August 2023
First Online: 26 September 2023
Declarations
:
: F.D. Richard Hobbs reports funding from AstraZeneca to cover meeting attendances and the operationalization of TACKLE in the UK as the UK principal investigator; has received funding from UK Research and Innovation and the National Institute for Health and Care Research (NIHR) for national Urgent Public Health COVID-19 trials, and as director of the NIHR Applied Research Collaboration, Oxford Thames Valley, and investigator on the Oxford Biomedical Research Centre (BRC) and NIHR MedTech. Hugh Montgomery is supported by the NIHR’s BRC at University College London Hospitals. He has received consultation fees from AstraZeneca and has consulted for Millfield Medical Electronics Ltd. on the development of a new Closed Circuit Continuous Positive Airway Pressure machine. Francisco Padilla has received personal fees and grants from Amgen, AstraZeneca, Boehringer Ingelheim, Ferrer, Kowa, Medix, Merck, Merck Sharp and Dohme, Novartis, Pfizer, Sanofi, Servier, and Silanes. Jesus Abraham Simón-Campos reports serving on advisory boards for Atea and Eli Lilly; and serves as a speaker for Pfizer, AstraZeneca, Roche, and Regeneron. Kenneth Kim has received research grants for the conduct of the TACKLE trial; reports funding from Regeneron, Eli Lilly, Merck, Pfizer, and Adagio; and serves as a speaker for Regeneron. Douglas Arbetter, Venkatesh Pilla Reddy, Seth Seegobin, Katie Streicher, Rolando M. Viani and Mark T. Esser are employees of, and hold or may hold stock in, AstraZeneca. Kelly W. Padilla was an employee of AstraZeneca at the time of this study and is now an employee of Immunovant, New York, NY, USA. Kelly W. Padilla holds stock in AstraZeneca, GSK (prior employee) and Trulab Inc (board member). Gavin C.K.W. Koh was an employee of AstraZeneca at the time of this study and is now an employee of Generate Biomedicines, Somerville, MA, USA. Gavin C.K.W. Koh holds stock in GSK. Eva Johnsson was an employee of AstraZeneca at the time of this study and is now an employee of Grunenthal, Stockholm, Sweden. Alison Templeton was an employee of AstraZeneca at the time of this study and is now an employee of Regeneron Pharmaceuticals, Inc, Uxbridge, UK.
: The study adhered to Good Clinical Practice guidelines and the Declaration of Helsinki, Council for International Organizations of Medical Sciences International Ethical guidelines, applicable International Conference on Harmonisation Good Clinical Practice guidelines, and all applicable laws and regulations. All participants provided informed, written consent.